Acacetin Review: Is Acacetin The Best Natural PCT Out There? (4'-methoxy-5,7-dihydroxyflavone)



Acacetin has another name - 4'-methoxy-5,7-dihydroxyflavone – which explains why a lot of people prefer to simply call it “Acacetin!”

Whatever you call it though, this is a relatively new player when it comes to muscle-building supplementation that has been enjoying a lot of attention on forums. The basic idea between Acacetin is to work as an anti-aromatase. What this means, is that it can reduce estrogen production, and help to support a healthy hormonal balance. 

For more information on what this means and why it should matter to you, read on.

Acacetin Basics

Acacetin is actually what you would call a flavone, which tells you that it comes from entirely natural sources. It is completely legal and has no noticeable side effects.

Acacetin is also what is referred to as an aromatase inhibitor. This means that it can block the production and effectiveness of aromatase in the body, which in turn means that it can help to prevent its action. What does aromatase do? It converts testosterone into estrogen!

This makes Acacetin an extremely popular option in a lot of stacks, especially owing to its natural status and lack of side effects and risks.

By preventing the action of aromatase, you can avoid losing testosterone to estrogen conversion. This immediately means you will have more testosterone in your system, which in turn will result in increased muscle mass and fat loss. You’ll be stronger, more energetic, and more driven, and you’ll find your muscle grows faster than it otherwise would.


What many people don’t recognize is that Acacetin is also anti-cortisol: and that this also significantly enhances its effects.

The reason this is significant is that cortisol is actually a testosterone agonist. What this means, is that you have a balance of testosterone and estrogen in your system, and when one of those substances increases, the other will necessarily also decrease in equal proportions. This is one reason that getting stressed (cortisol is the stress hormone) can be so harmful to muscle mass.

What’s more, is that cortisol also causes a spike in the hunger hormone leptin, encouraging unhealthy snacking. This also results in an increase in a substance called myostatin. Myostatin is especially harmful to bodybuilders, seeing as it is the chemical that triggers the body to being breaking down muscle!

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Risks and Side Effects

As mentioned, there are no known side effects associated with this natural product. Keep in mind that excessively low levels of estrogen can actually be harmful, and might lead to joint pain and inflammation. Fortunately, Acacetin also happens to be anti-inflammatory, meaning it can help to combat this. As long as you follow the directions, you won’t find that it triggers any unwanted effects.

In a Stack

Acacetin can be a powerful bodybuilding supplement when taken on its own and contributes to a hard and chiseled physique. At the same time though, Acacetin also has the benefit of helping to support the effect of other products.

That’s because the action of aromatase normally means that anything that raises testosterone will also necessarily raise estrogen. This is why many of the most powerful bodybuilding supplements can also risk increasing weight gain (water weight and fat weight), gynecomastia (the formation of male breasts), and mood swings.

When you take Acacetin, you can increase testosterone while at the same time preventing that from being converted to estrogen. This way, you are able to significantly increase the potency and safety of many other products.

At the same time, taking Acacetin will help you to boost your testosterone production and reduce the lingering effects of estrogen following a steroid cycle. This makes Acacetin a very popular choice for many using a PCT (post cycle therapy) stack. Taking it after you have used other supplements will help you to reduce your risk of hormone imbalance, weight gain, depression, and impotence.


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You can use Acacetin daily and don’t need to worry about PCT or contraindications. It works especially well as mentioned when added to a general hormone-support stack, or anything intended to build extra muscle. At the same time, Acacetin is also very effective when paired with other substances that can help to support muscle growth in a natural and safe way. Other great supplements to include in a stack include fish oil, vitamin D, beta-alanine, creatine, etc.

It is highly recommended that you consider using Acacetin in conjunction with prohormones which increase testosterone in the body and which can otherwise result in elevated estrogen levels. A well-designed stack will balance these kinds of ingredients in order to provide a healthy increase in testosterone with no risk of unwanted side effects. 

As the demand for Acacetin grows, you will likely see it cropping up in many more products and being spoken about much more commonly. For now, it can be your secret weapon!


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